2感染损害树突状细胞和T细胞反应
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2感染损害树突状细胞和T细胞反应

时间:2020-08-05 18:56来源:美高梅官方网-首页 作者:采集侠 点击:
本期文章:《免疫》:Online/在线发表 香港大学Zhiwei Chen、Kwok-Yung Yuen等研究人员的最新发现表明,急性SARS-CoV-2感染会损害树突状细胞和T细胞反应。2020年8月3日,《免疫》杂志在线发表

本期文章:《免疫》:Online/在线发表

香港大学Zhiwei Chen、Kwok-Yung Yuen等研究人员的最新发现表明,急性SARS-CoV-2感染会损害树突状细胞和T细胞反应。2020年8月3日,《免疫》杂志在线发表了这项成果。

通过调查17例急性和24例康复期患者,研究人员发现急性SARS-CoV-2感染导致广泛的免疫细胞减少,包括T、NK、单核细胞和树突状细胞(DC)。DC随功能障碍而显著降低,而cDC:pDC比率在急性重症患者中增加。除淋巴细胞减少症外,尽管在患者中迅速大量产生中和抗体,但在症状发作后的前三周内,受体结合域(RBD)和核衣壳蛋白(NP)特异性T细胞反应延迟。而且,急性RBD和NP特异性T细胞应答比CD8 T细胞包括了相对更多的CD4 T细胞。

 

这些发现表明,受损的DC和强抗体的反转以及应答较弱的CD8 T细胞,可能会导致急性COVID-19发病,并可能影响疫苗的开发。

 

据了解,SARS-CoV-2大流行已导致数百万人感染,但宿主免疫应答在早期COVID-19发病机理中的作用仍不清楚。

 

附:英文原文

Title: Acute SARS-CoV-2 infection impairs dendritic cell and T cell responses

Author: Runhong Zhou, Kelvin Kai-Wang To, Yik-Chun Wong, Li Liu, Biao Zhou, Xin Li, Haode Huang, Yufei Mo, Tsz-Yat Luk, Thomas Tsz-Kan Lau, Pauline Yeung, Wai-Ming Chan, Alan Ka-Lun Wu, Kwok-Cheung Lung, Owen Tak-Yin Tsang, Wai-Shing Leung, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Zhiwei Chen

Issue&Volume: 2020-08-03

Abstract: The SARS-CoV-2 pandemic has resulted in millions of infections yet the role of host immune responses in early COVID-19 pathogenesis remains unclear. By investigating 17 acute and 24 convalescent patients, we found that acute SARS-CoV-2 infection resulted in broad immune cell reduction including T, NK, monocyte and dendritic cell (DC). DCs were significantly reduced with functional impairment, and cDC:pDC ratios were increased among acute severe patients. Besides lymphocytopenia, although neutralizing antibodies were rapidly and abundantly generated in patients, there were delayed receptor binding domain (RBD)- and nucleocapsid protein (NP)-specific T cell responses during the first 3 weeks post symptoms onset. Moreover, acute RBD- and NP-specific T cell responses included relatively more CD4 T cells than CD8 T cells. Our findings provided evidence that impaired DCs, together with timely inverted strong antibody but weak CD8 T cell responses, may contribute to acute COVID-19 pathogenesis and have implications for vaccine development.

DOI: 10.1016/j.immuni.2020.07.026

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30333-2

期刊信息

Immunity:《免疫》,创刊于1994年。隶属于细胞出版社,最新if:21.522
官方网址:https://www.cell.com/immunity/home
投稿链接:https://www.editorialmanager.com/immunity/default.aspx

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